Levich Institute Seminar Announcement, 05/16/2006
Steinman Hall, Room #312
(Chemical Engineering Conference Room)
Professor Tom McLeish
University of Leeds
Department of Physics and Astronomy
"Come on Feel the Noise (in Single Biomolecules) "
Atomic Force Microscopy and other techniques are increasingly used to measure the force profile on extension of singel biomolecules such as proteins, nucleic acids and polysaccharides. The noise in the signal is usually treated as a nuisance, but it contains a lot of information in its power spectrum. We look at simple extensions of polymer dynamics models that serve to interpret the noise spectrum as a function of extension in terms of the energy landscape of monomeric transitions. The models are applied to recent experimental results on polysaccharides obtained at Leeds.
BRIEF ACADEMIC/EMPLOYMENT BACKGROUND:
Molecular polymer rheology and dynamics, biological physics of protein folding, self-assembly and allostery