Levich Institute Seminar Announcement, 05/03/2011
Tuesday, 05/03/2011
2:00 PM
Steinman Hall, Room #312
(Chemical Engineering Conference Room)

Professor Anthony McHugh
Lehigh University
Department of Chemical Engineering

"Phase Inversion Membranes and Drug Delivery: Experiment and Modeling"


ABSTRACT


Polymeric systems are the preferred form of delivery vehicle for a wide variety of controlled release applications. This talk will review studies in our laboratory on experiment and modeling of release systems produced by phase inversion. Experiments elucidate the interplay between phase inversion kinetics, morphology development and the concomitant drug distribution within and release kinetics from the formed matrix. The goal is to achieve maximum drug loading with minimal bursting (large initial release of drug). Modeling demonstrates the controlling roles of drug dissolution rate and particle distribution within the matrix on the release rate kinetics.

BRIEF ACADEMIC/EMPLOYMENT HISTORY

  • Lehigh University; 2003-present, Ruth H. and Sam Madrid Professor and Chair of Chemical Engineering
  • University of Illinois, Urbana-Champaign, 1979-2003, Associate/Full Professor, Chemical Engineering
  • Lehigh University, 1971-1979, Assistant/Associate Professor, Chemical Engineering
  • University of Delaware, (Chemical Engineering), Ph.D., 1972; University of Delaware (Chemical Engineering)

RECENT RESEARCH INTERESTS:

Phase inversion and drug delivery from polymeric systems Modeling of flow-enhanced crystallization in polymer processing Rheology and rheo-optics of polymer solutions and melts