Thrombosis is the formation of a blood clot in a blood vessel. When thrombosis occurs in the brain, it would cause stroke; when occurs in the heart, it would cause heart attack. If a thrombus breaks and travels to the lung, it would cause pulmonary embolism and may lead to death. Although many studies have led to a better understanding of the mechanical mechanisms for the thrombus formation, they have been conducted under the conditions that the flow is either retarded (flow stasis) or disturbed (secondary flow), or the vessels are injured/damaged. Instead, the first part of my talk will show that thrombi could be formed in non-injured bent/stretched microvessels with a normal laminar blood flow by the localized hydrodynamic stimuli. Photodynamic therapy (PDT), or light/dye treatment, has been widely used to treat a variety of cancers and cardiovascular diseases. Light/dye induced thrombi are desirable for killing tumors, but undesirable in microvessels of normal tissues. To prevent unwanted thrombosis, we need to understand its formation mechanisms. Therefore, the second part of my talk is to explain the structural mechanisms by which light/dye induces thrombosis in the microcirculation.
BRIEF ACADEMIC/EMPLOYMENT BACKGROUND:
Dr. Bingmei Fu received her B.S., M.S. from the Department of Modern Mechanics of the University of Science and Technology of China in 1985 and 1988, respectively. Then she worked as an assistant professor for one year in Southwest Jiaotong University before she came to the U.S. in 1989. She had been working with Dr. Sheldon Weinbaum to develop transport models for the inter-endothelial cleft and obtained a Ph.D. in Mechanical Engineering from the City University of New York in 1995. After working with Dr. Roy Curry on in vivo single microvessel permeability for three years as a NIH postdoctoral fellow in the School of Medicine, University of California, Davis, she joined the Department of Mechanical Engineering at the University of Nevada, Las Vegas in 1998 as an assistant professor and was promoted to a tenured associate professor in early 2004. She moved to the Department of Biomedical Engineering of the City College of the City University of New York as a tenured associate professor in the fall of 2004 and was promoted to a full professor in 2010.
CURRENT RESEARCH INTERESTS:
Dr. Fu's major research activities involve modeling nano and micro transport phenomena in the microcirculation such as in transvascular, transcellular and transinterstitial processes, and in vivo animal study on understanding mechanisms of microvessel permeability related diseases. Her current research is focused on how to control microvessel permeability and cell adhesion molecules in vascular endothelium to prohibit tumor metastasis, how flow and vessel permeability conditions affect thrombus formation and how to deliver therapeutic drugs to the brain through the blood-brain barrier and the cerebrospinal fluid. These research projects have been supported by the NIH, NSF and Andrew Grove Foundation, which includes a NSF CAREER award.