Seminar Announcement, 03/17/2015
Levich Institute Seminar Announcement, 03/17/2015
Tuesday, 03/17/2015
2:00 PM
Steinman Hall, Room #312
(Chemical Engineering Conference Room)

Dr. Christine Vauthier
CNRS at Institut Galien Paris Sud

"Intravenous Delivery of siRNA to Tumors with Polymer Nanoparticles"

ABSTRACT


Antisense strategies are among novel therapeutic approaches proposed to fight against cancers. Based on the reduction of the expression of an oncogene, therapeutic molecules include short fragments of nucleic acids allowing a very high degree of specificity of the treatment. However, because of the physico-chemical properties of these molecules and their high susceptibility to enzymes, their use in clinics is pending to their formulation in drug carriers including nanomedicines. The aim of our work was to explore the performance of a polymer nanoparticle made of a degradable polymer to deliver active anticancer si-RNA. The si-RNA loaded nanoparticles were administered intravenously to two models of tumor bearing mice considering tumors with different junction oncogenes. According to the results, the method of delivery of si-RNAs proposed in this work was successful encouraging to continue the development of the nanoparticles proposed in this work on their therapeutic potential. Other perspectives considering the elucidation of more fundamental aspects of the delivery method will be discussed in the presentation.

BRIEF ACADEMIC/EMPLOYMENT HISTORY

Christine VAUTHIER, PhD, is Director of Research at the CNRS (Centre National de la Recherche Scientifique). She received her Ph. D. in polymer chemistry in 1986 from the University Louis Pasteur at Strasbourg, France. She joined the University of Paris South, Faculty of Pharmacy in 1987 as a research assistant. During her carrier, she was a visiting scientist at the Center for Chemical Controlled Delivery, University of Utah, USA and at the Federal University of Pernambuco, Recife, Brazil. Currently, she is at the Institut Galien Paris Sud, UMR CNRS 8612, Université Paris Sud in France. Christine VAUTHIER is authors of more than 100 research papers and over 20 review papers and book chapters on nanoparticle preparation and characterization methods and on the application of nanoparticles as drug delivery systems. She has presented over 100 communications and many invited conferences. She serves as an editor for Pharmaceutical Research.

RECENT RESEARCH INTERESTS

Designing biodegradable polymer nanoparticles for mucosal and intravenous administration of drugs including antisense oligonucleotides and siRNA, my research interest is to understand better how polymer nanoparticle properties and characteristics influence biodistribution of drugs. The aim is to improve the understanding of toxicological risks associated with the use of this kind of nanomedicines and to rationalize their design.



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